Mendelian randomization analysis of 34,497 German Holstein cows to infer causal associations between milk production and health traits

Table 3 Horizontal pleiotropic variants that were identified by the HEIDI method

Chr	Position	Milk yield		Health trait
Chr	Position	\(b\) (SE)	\({p}_{GWAS}\)	Trait	\(b\) (SE)	\({p}_{GWAS}\)
6	82,842,199	0.055 (0.007)	< 0.0001	MAS	− 0.044 (0.012)	0.0002
6	85,526,144	− 0.110 (0.015)	< 0.0001	DD	− 0.055 (0.021)	0.0087
6	87,304,351	0.112 (0.008)	< 0.0001	MAS	− 0.060 (0.011)	< 0.0001
6	87,719,366	0.093 (0.013)	< 0.0001	DD	0.047 (0.020)	0.0177
14	6,054,352	0.110 (0.011)	< 0.0001	PH	0.038 (0.016)	0.0032
19	17,893,592	0.078 (0.013)	< 0.0001	MAS	0.052 (0.018)	0.0200

Shown are the chromosome (Chr) and position (in bp) of the variant, together with the effect size (\(b\)), standard error (SE) and p-value (\({p}_{GWAS}\)) from the association study for milk yield and the respective health trait

ISSN: 1297-9686