Fig. 5

Annotation of the TSHR missense SNPs showing positive signatures of selection. a TSHR protein sequence analysis. The protein coordinates are based on the NP_001009410.1 NCBI protein. Protein sequences with the mutation present in sheep and 11 vertebrates are provided. b TSHR protein 3D structure model predicted by Swiss-model and Missense 3D. The left part of the panel shows the 276 amino acid change from Asp to Ala, with the wild type in turquoise and the mutant type in red